NRP1 and cancer: Activin functions as a tumor‐suppressor protein and potently inhibits the growth of primary cultures of human follicular epithelial thyroid cells.25 Transmembrane receptors, such as G protein‐coupled receptor 30, play a fundamental role in cell proliferation, invasion, and metastasis in THCA.26 The Kyoto Encyclopedia of Genes and Genomes enrichment analysis of hypermethylation/low‐expression genes showed that methylation may affect the development and progression of THCA through the cancer‐associated pathways and AMPK signaling pathway.