Because Werner syndrome is caused by mutations in WRN gene that encodes a RecQ DNA helicase important to DNA replication and chromatin maintenance (Li et al., 2016b; Wu et al., 2018; Yu et al., 1996; Zhang et al., 2015), genomic instability and heterochromatin disorganization manifest in WS pathogenesis (Li et al., 2016b; Murfuni et al., 2012; Ren et al., 2017a; Ren et al., 2011; Seki et al., 2008; Shamanna et al., 2017; Wu et al., 2018; Zhang et al., 2015). Here, WRN is linked to Werner syndrome.