WRN participates in a continuum of cellular processes, spanning from DNA replication, transcription, repair, recombination as well as heterochromatin maintenance at telomeric and centromeric regions, thus pointing WS pathogenesis to genomic and epigenomic instability (Kudlow et al., 2007; Lebel, 2001; Li et al., 2016b; Wu et al., 2018; Zhang et al., 2015). Here, WRN is linked to Werner syndrome.