PGE-2 is one of the major mediators of inflammation in colorectal cancer (CRC) development and progress [34], same as IL-6, which has been considered as a key regulator of CRC development [35] and increased quantities of plasma IL-6 were correlated with a poor prognosis in a variety of cancers, including colon cancer [36]. Here, IL6 is linked to colorectal carcinoma.