INS and Hypoglycemia: Hence, insulin Degludec (IDeg), an ultra-long-acting basal analog approved by the US Food and Drug Administration (FDA) on September 25, 2015 was developed with the properties of having a flat peakless profile, less day-to-day variability, once-daily dosing, flexible timing of administration, long-acting profile (> 42 h), low overall and nocturnal hypoglycemia, a mean elimination half-life of ~ 25 h and an ability to mix with other insulins.