20 patients (Duration of diabetes 3.09 ± 2.61 years) were shifted from Glargine to insulin degludec (Group A) (Basal insulin decreased by 10% while bolus insulin kept as same) and 10 patients were insulin naïve patients (Group B) in whom basal characteristics (BMI, HbA1c, FPG, basal and bolus insulin doses) were retrospectively collected at 1 month after diagnosis. The gene discussed is INS; the disease is diabetes mellitus.