The results show that gene signatures related to ECM remodeling, angiogenesis, apoptosis, epithelial−mesenchymal transition, and p53 suppression were significantly enriched in the Twist1/Prrx1/TNC (+/+/+) group in all 11 cancer types (Supplementary Fig. 8c and Supplementary Table 3). Here, PRRX1 is linked to cancer.