TP53 and lung adenocarcinoma: In light of the importance of chemotherapeutic resistance and DDR pathways, future work should address the following key questions: (1) whether and how does RDM1 in DNA damage repair is related to its oncogenic functions in lung adenocarcinoma; (2) how does RDM1 regulate P53; and (3) can RDM1 be targeted for alleviating cisplatin-resistance in the therapy of lung adenocarcinoma?