The potency of NLRP36K>R to activate caspase-1 was comparable to that of reported CAPS disease mutants, such as NLRP3R260W, NLRP3E690K and NLRP3E692K (Fig. 5b, c and Supplementary Fig. 4a), which served as controls40. This evidence concerns the gene CASP1 and cryopyrin-associated periodic syndrome.