Of note, mutation of single residues reported in CAPS disease mutants (NLRP3R260W, NLRP3E690K and NLRP3E692K) did not reduce the overall sumoylation smearing pattern on NLRP3 (Fig. 5f, and Supplementary Fig. 4d). This evidence concerns the gene NLRP3 and cryopyrin-associated periodic syndrome.