IL6 and neoplasm: Aiming to shed some light on the role played by CSCs in the overall tumorigenic process, the present work endorsed a model for CSCs’ dedifferentiation in which the tumor-mediated co-option of non-malignant microenvironment cells leads to an increase in IL-6 and Activin-A levels in the tumor microenvironment, which in turn drive tumor cells’ dedifferentiation, and consequently, CSCs’ formation.