The mutation distribution was associated with the COO subtype, such as MYD88 (particularly L265P), PIM1, and CD79B in ABC DLBCL; EZH2, BCL2, and GNA13 in GCB DLBCL or STAT6, SOCS1, and MFHAS1 in PMBL. Here, EZH2 is linked to diffuse large B-cell lymphoma.