In contrast to PDX, primary T-ALL cells from refractory patients (N = 7) were highly sensitive to TRAIL, with almost 40% specific cell death after 24 h; interestingly, this effect was further enhanced by NS1619 and DHEA, with > 60% specific cell death after 24 h (Fig. 6A). The gene discussed is TNFSF10; the disease is acute lymphoblastic leukemia.