Finally, comparison of DLEU1 expression levels with those of putative target genes in primary HNSCC in TCGA datasets revealed that DLEU1 expression positively correlates with HAS3, CD44, TP63, BCL2L10, SMYD2, KDM1B, and GALNT3 expression, which suggests expression of these genes may be regulated by DLEU1 in primary tumors (Supplementary Fig. 11). Here, HAS3 is linked to head and neck squamous cell carcinoma.