A recent consensus in the literature indicates that the molecular weight for NRF-2 occurs between 95–100 kDa23 therefore, bands detected at mass 95 kDa were used quantify a significant decrease in cytosolic NRF-2 levels in the AD cohort (p = 0.004) (Fig. 4D and E, refer to Supplementary Fig. S2), suggesting that NRF-2 levels are inherently lower in the AD-STG and/or that NRF-2 may be sequestered to the nucleus in this cohort. This evidence concerns the gene NFE2L2 and Alzheimer disease.