Chen et al. (2018) show that pleomorphic adenoma gene 1 (PLAG1) is one of the consistently overexpressed genes in Wilms tumor, where MIRPG mutations are seen. The 3′ untranslated region analysis of PLAG1 showed microRNA-binding sites for 5p microRNAs, miR34, and miR16, which are down-regulated in Wilms tumor. PLAG1 is a known transcription factor, and one of its important target genes in both disease and development is IGF2 (Declercq et al. 2008). This evidence concerns the gene IGF2 and Nephroblastoma.