In particular, recent findings have shown that T-cell intracellular antigen 1 (TIA1) and other RBPs interact with hyper-phosphorylated tau and accumulate in tandem with tau pathology in diseases such as Alzheimer’s disease (AD) and frontotemporal dementia (FTD) [37, 38]. This evidence concerns the gene MAPT and early-onset autosomal dominant Alzheimer disease.