SHANK3 and infection: A three-way ANOVA for repeated measures with protein (EAAT2, Shank3) and ROI (cortex, striatum, thalamus) as within-subject factors and infection status as between-subject factor showed a significant structure by infection interaction (F2,5.6 = 6.64; p = 0.039), and post hoc two-sample t tests further revealed a significant infection-related reduction of EAAT2 (t3.0 = 4.08; p = 0.027).