MS results revealed an infection-related increase of the synaptosomal levels of proteins like interferon-inducible GTPase 1 (IIGP1), immunity-related GTPase (IGTP), interferon-induced protein with tetratricopeptide repeats 3 (IFIT3), and guanylate-binding protein 2 (GBP2), which are all signature molecules for the infection with the intracellular pathogen T. gondii. Moreover, the signaling molecule signal transducer and activator of transcription 1-alpha/beta (STAT1) was elevated during chronic infection, indicating an active host defense mechanism. Here, STAT1 is linked to infection.