CLEC10A and amyotrophic lateral sclerosis: By mapping RNA-Seq reads to HML-2 loci, a recent study identified HML-2 locus HERV-K(I) to be downregulated 1.09-fold, and loci c7_C and c10_A to be upregulated 1.13-fold and 1.11-fold, respectively, in ALS versus control samples, though with inconclusive statistical support [46].