Taken together, our quantification of overall HERV-K(HML-2) transcript levels in more than 100 ALS-derived (40 donors) and control tissue samples (27 donors) revealed considerable variability in transcript levels between samples and tissue types, yet no significant differences in HML-2 transcript levels when comparing ALS-derived and control samples within tissue types. This evidence concerns the gene CLEC10A and amyotrophic lateral sclerosis.