NMRs possess enhanced protein stability and increased proteasomal activity in the liver [9, 10], negligible levels of cellular senescence [11], increased resistance to irradiation-induced senescence and apoptosis [12], over-activation of pathways that contribute to stress resistance (e.g., the nuclear factor erythroid2-related factor 2 (NFE2L2, previously NRF2/Nrf2) in the liver and fibroblasts and p53 in fibroblasts) [3, 13], atypical expression of extracellular matrix components by fibroblasts, such as high molecular mass hyaluronan, that confer resistance against cancer development [14]. This evidence concerns the gene NFE2L2 and cancer.