MC4R and obesity due to melanocortin 4 receptor deficiency: As delineated in Table 1, of those 120 Bedouin control non-related individuals, one carried a heterozygous c.606C > A p.F202 L MC4R mutation previously associated with obesity, and two individuals carried heterozygous synonymous variants (c.594C > T, c.690C > T) previously described as possibly associated with obesity, though likely non-pathogenic [25–27].