KIF5A mutations account for autosomal dominant spastic paraplegia (SPG) 10 [5–7], mutations in KIF1A lead to autosomal recessive SPG30 or to autosomal dominant cases of complex HSP [8,9] and mutations in KIF1C have been found in autosomal recessive SPG58/SPAX2 [10–13]. Here, KIF1C is linked to autosomal dominant complex spastic paraplegia.