TLR4 and infection: By detecting extracellular T. cruzi through TLR2 and TLR4 at the moment of the infection, or intracellular T. cruzi through TLR9 and TLR7, the cardiomyocytes should activate the MyD88 pathway and induce CCL5 that will focus the recruitment of cytotoxic CD8+ T cells towards the infected cell.