The presumption that TG trend indicators have predictive qualities at all is based on the following aspects: First, the instructions for use for DG5 and FL (and, possibly, other CGM systems) provided by the respective manufacturer indicate that trend arrows show where glucose “is heading.”6,7 Second, insulin pump systems incorporating predictive low glucose management have to estimate impending hypoglycemia, and trend arrows would be the logical basis for such estimations. The gene discussed is INS; the disease is Hypoglycemia.