In two landmark trials, participants were instructed to consider trend indicators when delivering premeal insulin doses by adjusting doses by up to ±20%.8,9 In recently published survey data, diabetes patients acknowledged that they would increase premeal insulin doses by up to 400% in case of rapidly rising glucose concentrations or possibly skip premeal insulin doses in case of rapidly decreasing glucose concentrations.3 Recent recommendations also suggest that circumstances like meals should be taken into account when using trend indicators for insulin dose adjustments.5,10. The gene discussed is INS; the disease is diabetes mellitus.