As mentioned, CD4+CD25+Foxp3+ cells of PCM patients present increased expression of LAP-1 [45,90], and CD4+CD25+ cells purified from peripheral blood of PCM patients with active disease produce high amounts of IL-10 and soluble TGF-β when stimulated in vitro [90]. Here, TGFB1 is linked to paracoccidioidomycosis.