Natural exposure to allergens leads to increased inflammatory reactions andincreased bronchial responsiveness, as well as to elevated eosinophil counts in thebronchoalveolar lavage, just like hypovitaminosis D.29Although VD is correlated to asthma in a manner similar to IgE, there is alack of experimental studies that demonstrate how this interaction actuallyoccurs. The gene discussed is IGHE; the disease is asthma.