Consistent with past studies using soluble TGF‐β–binding proteins, we observed that simple sequestration of TGF‐β can, in some contexts, significantly reduce its immunosuppressive potential.10, 33 In addition to limiting TGF‐β signaling in immune cells, TGF‐β sequestration may also reduce TGF‐β's ability to promote tumor metastasis via mechanisms such as induction of the epithelial‐mesenchymal transition.34 In comparison to the TGF‐β DNR, the TGF‐β CAR provided superior support of anti‐tumor functions in both the CD20 CAR/Raji and NY‐ESO‐1 TCR/M407 experimental systems (Figure 1c–f). Here, TGFB1 is linked to neoplasm.