Here, we demonstrate that TGF‐β CAR‐T cells can also protect neighboring immune cells from the suppressive effects of TGF‐β by enabling tumor‐targeted CD8+ T cells to retain cytolytic activity in the presence of TGF‐β, and by discouraging CD4+ T cells from TGF‐β–induced Treg differentiation. This evidence concerns the gene TGFB1 and neoplasm.