RBPJ and myocardial infarction: In our study, we observed that blocking the canonical Notch signaling pathway by RBP-J knockout could increase cardiomyocyte apoptosis in the border zone of ischemic heart tissue following MI, which suggested that one cardioprotective effect brought by activation RBP-J-mediated Notch pathway is involved in the regulation of cardiomyocyte apoptosis.