In order to investigate whether HNF-1B protein expression was restricted to the adenocarcinomas of pancreatic ductal origin, HNF-1B IHC was performed on a total of 278 common carcinomas from other organ systems, including cholangiocarcinoma (intrahepatic and extrahepatic biliary tracts), ampullary region, gallbladder, colorectum, distal esophagus, stomach, hepatocellular, lung adenocarcinoma, lung squamous cell carcinoma, breast, prostate, ovary, uterus, bladder urothelial, and kidney. This evidence concerns the gene HNF1B and adenocarcinoma.