HNF-1B was highly expressed in adenocarcinomas along the pancreaticobiliary tract, including PDAC, intrahepatic and extrahepatic cholangiocarcinomas, ampullary adenocarcinomas, and gallbladder adenocarcinomas with nuclear and/or cytoplasmic staining pattern. The gene discussed is HNF1B; the disease is gallbladder adenocarcinoma.