APC and Familial adenomatous polyposis: In the sample cohort we observed a statistically significant difference between the phenotypic FAP groups (based on APC variant location) and age of polyposis diagnosis (log-rank p = 0.0010, Wilcoxon p = 0.0004 and Tarone ware p = 0.0005); age where 50% of population was polyposis free was 46 years for APC AFAP, 29 years for APC MCR and 37 years for APC, see Fig. 1.