This study was undertaken to determine whether CD36 variants could account for phenotypic variation observed in FAP patients, and we have observed a remarkable low age of polyposis diagnosis (16 years) in patients with APC mutations in the MCR harbouring the variant (AA) genotype of rs1761667 or the wildtype (AA) genotype of rs1984112, independent of each other and a much higher age of polyposis diagnosis for patients harbouring the wildtype genotype (GG) of rs1761667 in the APC AFAP mutation group. The gene discussed is CD36; the disease is polyposis.