For example, the mutation of E318K on melanoma-lineage-specific microphthalmia-associated transcription factor (MITF) can disrupt a SUMO consensus site, and lack of SUMOylation increased the transcriptional activity of MITF, thereby increasing the levels of other tumor promoting factors, such as HIF1α (Bertolotto et al., 2011; Yokoyama et al., 2011). The gene discussed is MITF; the disease is melanoma.