As in AIH, histological analysis of liver samples reveals an accumulation of PD1+Bcl6+ Tfh cells around the damaged interlobular bile ducts in PBC with chronic non-suppurative destructive cholangitis; these infiltrating Tfh cells organize follicle-like structures and collocate with B cells around the bile ducts (204). This evidence concerns the gene PDCD1 and autoimmune hepatitis.