No differences were found in the percentages of cTfh cells or within Tfh1, Tfh2, and Tfh17 subsets in RA patients, as compared to healthy controls or patients with undifferentiated arthritis, without correlation with DAS28 (124, 125) and Penatti et al. even observed lower frequencies of ICOS+ cTfh cells in patients with RA (122). The gene discussed is ICOS; the disease is rheumatoid arthritis.