We further determined whether the inhibition of migration and invasion of CRC cells by PSA treatment was related with the EMT process by examining the effect on the gene and protein expression level of the epithelial cell marker; E-cadherin (encoded by CDH1) and mesenchymal cell markers; N-cadherin (encoded by CDH2), snail family transcriptional repressor 1 or SNAIL (encoded by SNAI1), and snail family transcriptional repressor 2 or SLUG (encoded by SNAI2) using RT-PCR and western blot analysis, respectively. Here, SNAI2 is linked to colorectal carcinoma.