It is to note that, at least in PC and in LBC, CDKN1B mutations are less frequent in more aggressive/recurrent than in primary tumors, suggesting that the presence of these mutations could be linked to a more favorable scenario with respect to the one having a complete loss of function of p27 protein. The gene discussed is CDKN1B; the disease is CDH1-related diffuse gastric and lobular breast cancer syndrome.