Wexler et al. showed a significantly impaired quality of life in GH-deficient patients after treatment of acromegaly compared to GH-sufficient patients, as measured by the QoL-AGHDA, the Symptom Questionnaire Depression and SF36 questionnaires (19), while Vandeva et al. found that the absence of hypopituitarism independently predicted improvements in quality of life (10). The gene discussed is GH1; the disease is acromegaly.