Among the eight genes that inhibit growth in all HCC but not in non-cancerous models, we identify three genes that are controlling nodes in HCC RRN but not in non-cancerous RRN (Step 3, Supplementary File 5): PRKACA (protein kinase cAMP-activated catalytic subunit alpha), PGS1 (phosphatidylglycerophosphate synthase 1), CRLS1 (cardiolipin synthase 1). The gene discussed is PGS1; the disease is hepatocellular carcinoma.