CYP2C8 and metabolic dysfunction-associated steatohepatitis: The two non-synonymous SNPs, CYP2C8 rs11572080 and rs10509681, designating the ∗3 allele were previously linked to lower pioglitazone exposure (Tornio et al., 2008; Aquilante et al., 2013; Kawaguchi-Suzuki and Frye, 2013), which we have shown is an important determinant of response in patients with NASH (Kawaguchi-Suzuki et al., 2017).