LPL rs270 variant allele was associated with smaller chance of achieving the primary outcome (p = 0.027) and NASH resolution (p = 0.019) and worse changes in ballooning (p = 0.0048) and NAS (p = 0.0045), as well as smaller reduction in plasma ALT levels (p = 0.01). Here, LPL is linked to metabolic dysfunction-associated steatohepatitis.