ASGR1 and hepatocellular carcinoma: Inspired by the specific recognition between ASGPR and galactose (D’Souza and Devarajan, 2015), and the cluster glycoside effect (Dimick et al., 1999; Lundquist and Toone, 2002), which can effectively improve the affinity of carbohydrate ligands for their protein receptors, we employed galactose to build glycopolymer to obtain enhanced ASGPR-mediated hepatoma cellular binding and internalization.