When scores of <= 7 (n = 45) or > 7 (n = 9) were used to stratify the patients, neither MALDI-TOF/MS features (serum or urine) nor tPSA, fPSA and f/tPSA or PCA3 values were found to be statistically significant predictors of PCa grading at logistic regression. This evidence concerns the gene PCA3 and posterior cortical atrophy.