IF examination of frozen (Supplementary Fig. 3A) and paraffin-embedded ApcMin/+ intestinal sections (Fig. 4b), using two different anti-MFNG antibodies, confirmed that MFNG levels were significantly reduced in the adenoma tissue, in clear contrast to the consistent staining observed in adjacent normal crypts and at the base of the tumor area. The gene discussed is MFNG; the disease is adenoma.