Importantly, we further analyzed Dll4 levels in a subset of CRC samples and found that ten out of 11 tumors that were characterized as ICN1 high/JAG1 low contained high levels of Dll4, nine of them being MFNG positive (Supplementary Table 3), further supporting that tumors expressing MFNG may induce Notch1 through Dll4. Here, DLL4 is linked to colorectal carcinoma.