HR-weighted risk points were subsequently allocated to VHR karyotype (4 points), unfavorable karyotype (3 points), ≥2 HMR mutations (3 points), presence of an HMR mutation (2 points), absence of type 1/like CALR mutation (2 points), presence of constitutional symptoms (2 points), severe anemia defined by hemoglobin levels of <8 g/dl in women and <9 g/dl in men (2 points), moderate anemia defined by hemoglobin levels of 8–9.9 g/dl in women and 9–10.9 g/dl in men (1 point) and ≥2% circulating blasts (1 point). The gene discussed is CALR; the disease is anemia (phenotype).