FOXA3 and neoplasm: Other examples of trans-differentiation across germ layers are the induction of hepatocyte-like cells from fibroblasts by the ectopic expression of one of the FOXAs (FOXA1, FOXA2, or FOXA3) with HNF4 [106], or ectopic expression of FOXA3, GATA4, and HNF1a in combination with the inactivation of p19Arf, a tumor suppressor [107].