Finally, COX-2-dependent PGE2 induces the transactivation of epidermal growth factor receptor (EGFR) (Figure 1A), a transmembrane receptor tyrosine kinase of the Erythroblastic Leukemia Viral Oncogene Homolog ErbB family, involved in the development of colorectal (CRC) [21]. Here, EGFR is linked to colorectal carcinoma.