Evidence demonstrates that the expression and single nucleotide polymorphisms (SNPs) of CSF1R relate with survival and risk of lung cancer in never-smokers [15,16,17]; however, no studies have examined the association of CSF1R expression in TAMs with mortality or the prognostic interaction between CSF1R expression and smoking in lung adenocarcinoma. The gene discussed is CSF1R; the disease is lung adenocarcinoma.