Moreover, there are reports of an inverse relationship between patient survival and melanoma thickness and 25(OH)D3 serum levels, polymorphisms in the genes encoding the vitamin D receptor (VDR), the vitamin D binding protein, expression of the VDR and CYP27B1 expression [19,20,21,22,23,24,25] and complex relations with CYP24A1 [26]. This evidence concerns the gene VDR and melanoma.