HMOX1 and ischemia: Another study [73] reports that totarol (5) has vascular protective effects in vivo, by activating the protein kinase B/heme oxygenase-1 (PKB/HO-1) pathway, further increasing superoxide dismutase (SOD) and antioxidant glutathione (GSH) levels, which leads to ischemia-induced brain injury suppression.