While CpG island 1 within the EGFL7 promoter was found unmethylated in almost all glioma samples, CpG island 2 responsible for miR‐126/126* expression was mostly methylated with the exception of the histone H3 G34‐mutant GBM subgroup (G34R; Fig 1B). Here, EGFL7 is linked to central nervous system cancer.