To understand the role of tau on nucleolar function and impact of cellular stress on its nucleolar localisation, here we show that nuclear non-phosphorylated tau localises within the nucleolus in undifferentiated and differentiated human SHSH5Y neuroblastoma cells, where it associates with TIP5, the major subunit of the Nucleolar Remodelling Complex (NoRC) and a key player of heterochromatin stability at constitutive heterochromatin and rDNA [34]. The gene discussed is MAPT; the disease is neuroblastoma.