We and the others have reported that in mice, CD11b+Ly6G−Ly6Cmiddle + high MC were consistently and dramatically increased in hypercholesterolemic ApoE−/− mice that were fed with a high-fat diet [118], in Ldlr−/− mice [119], in HHcy mice [120], in miR155−/− mice [121], and in type 1 diabetes mellitus (T1DM) mice [122]. The gene discussed is ITGAM; the disease is type 1 diabetes mellitus.