TP53 and lung carcinoma: To determine whether the proliferation and cisplatin chemoresistance of lung cancer caused by TNFAIP8 resulted from the activation of p53 signalling, we transfected NCI-H460 and A549 cells with Ctrl-shRNA or TNFAIP8-shRNA2 and treated them (or not) with p53-shRNA (Fig. 6a, b).