In a comprehensive study of the genetics of UTUC, whole exome sequencing was performed in samples from 27 patients; FGFR3 alteration was detected in 60% (9 of 15) of high-grade tumors and in 37.5% (3 of 8) of > pT2 tumors [21]. Here, FGFR3 is linked to renal pelvis/ureter urothelial carcinoma.