Higher IGF-1 levels were found in HCC developing in non-cirrhotic liver compared to patients with cirrhosis (median (range) 61.1 ng/mL (17.4–230.5 ng/mL) vs. 39.0 ng/mL (9.6–239.6 ng/mL); p < 0.01). This evidence concerns the gene IGF1 and hepatocellular carcinoma.