Of note, this network is different from the canonical erb receptor tyrosine kinase signal transduction cascades focusing on immediate EGFR (epidermal growth factor receptor) or HER2 (human epidermal growth factor receptor 2) downstream signaling studied in many cancers and more similar to finding from our prior work identifying EGF and MET-mediated signaling as top regulators of cell fate and lineage specific progenitor cell differentiation in the liver [41]. This evidence concerns the gene ERBB2 and cancer.