It is intriguing to speculate that the hypothesis of a greater dependency on PDPK1 signaling in the early tumor-initiating events of ADM and PanIN formation, as seen in the transgenic animal studies, versus a later loss of addiction to canonical PDPK1 signaling and overtake by PDPK1 independent oncogenic events is commensurate with the cancer stem cell hallmark of tumor initiation by this cell population [12, 53]. This evidence concerns the gene PDPK1 and cancer.